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- Title
THE EFFICACY OF A TOPICAL SIALOGOGUE SPRAY CONTAINING 1% MALIC ACID IN PATIENTS WITH ANTIDEPRESSANT-INDUCED DRY MOUTH: A DOUBLE-BLIND, RANDOMIZED CLINICAL TRIAL.
- Authors
Gómez‐Moreno, Gerardo; Aguilar‐Salvatierra, Antonio; Guardia, Javier; Uribe‐Marioni, Alejandro; Cabrera‐Ayala, Maribel; Delgado‐Ruiz, Rafael Arcesio; Calvo‐Guirado, José Luis
- Abstract
Background One of the most important antidepressants side effects is dry mouth. The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid on patients affected by dry mouth caused by antidepressants drug. Materials and methods This research took the form of a double-blind, randomized clinical trial at Faculty of Dentistry of University of Granada (Spain). Seventy participants with antidepressant-induced dry mouth were divided into two groups: for the first 'intervention group' (35 subjects) a topical sialogogue spray (1% malic acid) was applied, while for the second 'control group' (35 subjects), a placebo spray was applied; for both groups, the sprays were applied on demand during 2 weeks. The Dry Mouth Questionnaire (DMQ) was used to evaluate dry mouth symptoms before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after application, were measured. Results Dry mouth symptoms improved after 1% malic acid topical spray application (p < .05). After 2 weeks of 1% malic acid application, unstimulated and stimulated salivary flows rates increased significantly (p < .05). Conclusions A sialogogue spray containing 1% malic acid improved dry mouth feeling of the patients suffering antidepressant-induced dry mouth and increased unstimulated and stimulated salivary flows rates.
- Subjects
MALIC acid; ANTIDEPRESSANTS; BLIND experiment; CLINICAL trials; ETIOLOGY of diseases; DRUG side effects; MOUTH abnormalities
- Publication
Depression & Anxiety (1091-4269), 2013, Vol 30, Issue 2, p137
- ISSN
1091-4269
- Publication type
Article
- DOI
10.1002/da.22017