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- Title
Arterial spin labeling for head and neck lesion assessment: technical adjustments and clinical applications.
- Authors
Martín-Noguerol, Teodoro; Kirsch, Claudia F. E.; Montesinos, Paula; Luna, Antonio
- Abstract
Purpose: Despite, currently, "state-of-the-art" magnetic resonance imaging (MRI) protocols for head and neck (H&N) lesion assessment incorporate perfusion sequences, these acquisitions require the intravenous injection of exogenous gadolinium-based contrast agents (GBCAs), which may have potential risks. Alternative techniques such as arterial spin labeling (ASL) can provide quantitative microvascular information similar to conventional perfusion sequences for H&N lesions evaluation, as a potential alternative without GBCA administration. Methods: We review the existing literature and analyze the latest evidence regarding ASL in H&N area highlighting the technical adjustments needed for a proper ASL acquisition in this challenging region for lesion characterization, treatment monitoring, and tumor recurrence detection. Results: ASL techniques, widely used for central nervous system lesions evaluation, can be also applied to the H&N region. Technical adjustments, especially regarding post-labeling delay, are mandatory to obtain robust and reproducible results. Several studies have demonstrated the feasibility of ASL in the H&N area including the orbits, skull base, paranasal sinuses, upper airway, salivary glands, and thyroid. Conclusion: ASL is a feasible technique for the assessment of H&N lesions without the need of GBCAs. This manuscript reviews ASL's physical basis, emphasizing the technical adjustments necessary for proper ASL acquisition in this unique and challenging anatomical region, and the main applications in evaluating H&N lesions.
- Subjects
HEAD tumors; MAGNETIC resonance imaging; HEAD; DOPPLER ultrasonography; NECK; TUMOR markers; MEDICAL artifacts; NECK tumors; MEDICAL needs assessment; PERFUSION
- Publication
Neuroradiology, 2021, Vol 63, Issue 12, p1969
- ISSN
0028-3940
- Publication type
Article
- DOI
10.1007/s00234-021-02772-1