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- Title
Two New Metabolites from the Endophytic Fungus Alternaria sp. A744 Derived from Morinda officinalis.
- Authors
Ying Wang; Hong-Xin Liu; Yu-Chan Chen; Zhang-Hua Sun; Hao-Hua Li; Sai-Ni Li; Ming-Li Yan; Wei-Min Zhang
- Abstract
Two new compounds isobenzofuranone A (1) and indandione B (2), together with eleven known compounds (3-13) were isolated from liquid cultures of an endophytic fungus Alternaria sp., which was obtained from the medicinal plant Morinda officinalis. Among them, the indandione (2) showed a rarely occurring indanone skeleton in natural products. Their structures were elucidated mainly on the basis of extensive spectroscopic data analysis. All of the compounds were evaluated with cytotoxic and α-glucosidase inhibitory activity assays. Compounds 11 and 12 showed significant inhibitory activities against four tumor cell lines; MCF-7, HepG-2, NCI-H460 and SF-268, with IC50 values in the range of 1.91-9.67 μM, and compounds 4, 5, 9, 10, 12 and 13 showed excellent inhibitory activities against α-glucosidase with IC50 values in the range of 12.05-166.13 μM.
- Subjects
ENDOPHYTIC fungi; ALTERNARIA alternata; MORINDA; INDANDIONE; MEDICINAL plants; GLUCOSIDASES
- Publication
Molecules, 2017, Vol 22, Issue 5, p765
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22050765