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- Title
Reference-strand-mediated conformation analysis of MHC alleles: a new method for high-resolution typing of the Ovar-DQB genes.
- Authors
Feichtlbauer-Huber, Petra; Stear, Michael J.; Fries, Ruedi; Buitkamp, Johannes
- Abstract
Evaluates the use of reference-strand-mediated conformation analysis (RSCA) as a new method for high-resolution typing of the Ovar-DQB genes. Consideration of RSCA as a reliable and robust typing method for Ovar-DQb alleles; Inability of conventional methods like hybridization with sequence-specific oligonucleotides to type sheep DQB alleles accurately; Potential of RSCA to be the method of choice for typing complex genetic systems with a large number of alleles due to nucleotide substitutions.
- Subjects
IMMUNOGENETICS; EXONS (Genetics); SHEEP; GENETIC polymorphisms; SPLIT genes; NUCLEOTIDES; ANIMAL breeding
- Publication
Immunogenetics, 2000, Vol 51, Issue 1, p65
- ISSN
0093-7711
- Publication type
Article
- DOI
10.1007/s002510050010