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- Title
Cognitive Impairment after Chemotherapy Related to Atypical Network Architecture for Executive Control.
- Authors
Piccirillo, Jay F.; Hardin, Frances Mei; Nicklaus, Joyce; Kallogjeri, Dorina; Wilson, Michael; Ma, Cynthia X.; Coalson, Rebecca S.; Shimony, Joshua; Schlaggar, Bradley L.
- Abstract
Objectives: A common complaint of cancer patients is the experience of cognitive difficulty during and after chemotherapy. We hypothesized that cognitive impairment may result from dysfunction in large-scale brain networks, particularly those involved in attentional control. Methods: Using a case-control design, this study includes women with a history of invasive ductal or lobular triple-negative breast cancer who completed standard adjuvant chemotherapy within 2 years of study entry. Women who reported cognitive impairment by the Global Rating of Cognition question were considered to be cases (n = 15). Women who reported no cognitive impairment were considered to be controls (n = 13). All enrolled participants were eligible for MRI investigation and underwent resting-state functional connectivity MRI. Results: Women who self-reported cognitive impairment were found to have disrupted resting-state functional connectivity, as measured by MRI, when compared to women who did not self-report cognitive impairment. These findings suggest that some women may be more sensitive to the standard treatments for breast cancer and that this increased sensitivity may result in functional connectivity alterations in the brain networks supporting attention and executive function. Conclusions: Neuroimaging analyses confirmed self-reported cognitive deficits in women with breast cancer treated with chemotherapy. © 2015 S. Karger AG, Basel
- Subjects
MISSOURI; THERAPEUTIC use of biochemical markers; ACADEMIC medical centers; ARCHITECTURE; BREAST tumors; COGNITION disorders; STATISTICAL correlation; FISHER exact test; MAGNETIC resonance imaging; MULTIVARIATE analysis; QUESTIONNAIRES; REGRESSION analysis; RESEARCH funding; SCALE analysis (Psychology); STATISTICS; T-test (Statistics); DATA analysis; CASE-control method; DESCRIPTIVE statistics; MANN Whitney U Test
- Publication
Oncology, 2015, Vol 88, Issue 6, p360
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000370117