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- Title
Efficacy of Rifampin-Moxifloxacin-Metronidazole Combination Therapy in Hidradenitis Suppurativa.
- Authors
Join-Lambert, Olivier; Coignard, Hélène; Jais, Jean-Philippe; Guet-Revillet, Hélène; Poirée, Sylvain; Fraitag, Sylvie; Jullien, Vincent; Ribadeau-Dumas, Florence; Thèze, Jacques; Le Guern, Anne-Sophie; Behillil, Sylvie; Leflèche, Anne; Berche, Patrick; Consigny, Paul Henri; Lortholary, Olivier; Nassif, Xavier; Nassif, Aude
- Abstract
Background: Antibiotics have been shown to improve hidradenitis suppurativa (HS) patients but complete remission is rare using these treatments. Objective: To assess the efficacy and safety of a combination of oral rifampin, moxifloxacin and metronidazole in long-lasting refractory HS. Methods: We retrospectively studied 28 consecutive HS patients including 6, 10 and 12 Hurley stage 1, 2 and 3 patients, respectively. Complete remission, defined as a clearance of all inflammatory lesions including hypertrophic scars, was the main outcome criterion of the study. Results: Complete remission was obtained in 16 patients, including 6/6, 8/10 and 2/12 patients with Hurley stage 1, 2 and 3, respectively (p = 0.0004). The median duration of treatment to obtain complete remission was 2.4 (range 0.9-6.5) and 3.8 months (range 1.6-7.4) in stage 1 and 2 patients, respectively, and 6.2 and 12 months in the 2 stage 3 patients. Main adverse events of the treatments were gastrointestinal disorders (64% of patients) and vaginal candidiasis (35% of females). Reversible tendinopathy and hepatitis occurred in 4 and 1 patient, respectively. Conclusions: Complete remission of refractory HS can be obtained using broad-spectrum antibiotics and Hurley staging is a prognostic factor of response to the treatment. Copyright © 2010 S. Karger AG, Basel
- Publication
Dermatology (10188665), 2011, Vol 222, Issue 1, p49
- ISSN
1018-8665
- Publication type
Article
- DOI
10.1159/000321716