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- Title
Influence of 1α,25-Dihydroxy vitamin D<sub>3</sub> on the Development and Steroid Hormone Receptor Contents of DMBA-Induced Rat Mammary Tumors.
- Authors
Noguchi, Shinzaburo; Tahara, Hideaki; Miyauchi, Keisuke; Koyama, Hiroki
- Abstract
The influence of 1α,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on the development and steroid hormone receptor contents of 7,12-dimethylbenzanthracene (DMBA)-induced rat mammary tumors was evaluated. Neither the incidence nor the size of the tumors was affected by the 1,25-(OH)2D3 treatment (1 or 2 μg twice a week for 16 weeks) but estrogen and progesterone receptor contents of the tumors were significantly lower in 1,25-(OH)2D3-treated groups as compared to the control group. These results demonstrate that 1,25-(OH)2D3 at doses producing mild hypercalcemia does not affect the development of DMBA-induced rat mammary tumors but decreases the estrogen and progesterone receptor contents of the tumors. Copyright © 1989 S. Karger AG, Basel
- Publication
Oncology, 1989, Vol 46, Issue 4, p273
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000226730