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- Title
Inhibition of neutrophil chemotactic factor production in comedonal bacteria by subminimal inhibitory concentrations of erythromycin.
- Authors
Akamatsu, H.; Kurokawa, I.; Nishijima, S.; Asada, Y.
- Abstract
The effect of 1/10 minimal inhibitory concentrations (sub-MIC) of erythromycin (EM) on human neutrophil chemotactic factor production in comedonal bacteria, Propionibacterium acnes strains, Propionibacterium granulosum strains and coagulase-negative staphylococcus (CNS) strains was assayed using the Boyden chamber method. Sub-MIC of EM significantly suppressed neutrophil chemotactic factor production in all strains of P. acnes, P. granulosum and CNS. Our results suggest that sub-MIC of EM may have an anti-inflammatory action by reducing the inflammatory capacity of comedonal bacteria in inflammatory acne.
- Publication
Dermatology (10188665), 1992, Vol 185, Issue 1, p41
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000247401