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- Title
Microwave-assisted synthesis of some new coumarin derivatives including 1,2,4-triazol-3-one and investigation of their biological activities.
- Authors
Kahveci, Bahittin; Yılmaz, Fatih; Menteşe, Emre; Ülker, Serdar
- Abstract
[Figure not available: see fulltext.] By using the microwave technology, a new protocol has been developed for the synthesis of new coumarin derivatives including 1,2,4-triazol-3-one skeleton. This protocol proves to be efficient and environmentally friendly in terms of easy work-up and good yields. All newly synthesized compounds were screened for their antimicrobial activity and lipase inhibition. Most of the compounds were found to be effective on Escherichia coli. N'-{[4-Amino-3-(2-bromobenzyl)-5-oxo-4,5-dihydro-1 H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2 Hchromene-3-carbohydrazide and N'-{[4-amino-3-(3,4-dichlorobenzyl)-5-oxo-4,5-dihydro-1 H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2 H-chromene-3-carbohydrazide had a good effect on lipase inhibition.
- Subjects
COUMARINS; BENZOTRIAZOLE; ANTI-infective agents; LIPASES; MICROWAVES
- Publication
Chemistry of Heterocyclic Compounds, 2015, Vol 51, Issue 5, p447
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-015-1714-5