We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial.
- Authors
Bedaiwy, M. A.; Falcone, T.; Sharma, R. K.; Goldberg, J. M.; Attaran, M.; Nelson, D. R.; Agarwal, A.
- Abstract
<bold>Background: </bold>The objective of this prospective controlled trial was to investigate the ability of a group of serum and peritoneal fluid (PF) markers to predict, non-surgically, endometriosis.<bold>Methods and Results: </bold>Serum and PF samples were obtained from 130 women while undergoing laparoscopy for pain, infertility, tubal ligation or sterilization reversal. Concentrations of six cytokines [interleukin (IL)-1beta, IL-6, IL-8, IL-12, IL-13 and tumour necrosis factor (TNF)-alpha] were measured in serum and PF, and reactive oxygen species (ROS) in PF, and levels were compared among women who were allocated to groups according to their post-surgical diagnosis. Fifty-six patients were diagnosed with endometriosis, eight with idiopathic infertility, 27 underwent tubal ligation or reanastomosis (control group) and 39 were excluded due to bloody PF. Only serum IL-6 and PF TNF-alpha could be used to discriminate between patients with and without endometriosis with a high degree of sensitivity and specificity (P < 0.001). A threshold of 15 pg/ml PF TNF-alpha provided 100% sensitivity and 89% specificity (positive likelihood ratio of 9.1 and negative likelihood ratio of 0). A threshold of 2 pg/ml for serum IL-6 provided a sensitivity of 90% and specificity of 67% (positive likelihood ratio of 2.7 and negative likelihood ratio of 0.14).<bold>Conclusions: </bold>By measuring serum IL-6 and PF TNF-alpha, it was possible to discriminate between patients with endometriosis and those without. Before these markers can be used as a non-surgical diagnostic tool, these data should be verified in a larger study.
- Publication
Human Reproduction, 2002, Vol 17, Issue 2, p426
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/17.2.426