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- Title
Addition of Buserelin to human menopausal gonadotrophins in patients with failed stimulations for IVF or GIFT.
- Authors
Smitz, J.; Devroey, P.; Camus, M.; Khan, I.; Staessen, C.; Van Waesberghe, L.; Wisanto, A.; Van Steirteghem, A.C.
- Abstract
The combined therapy of a gonadotrophin-releasing hormone agonist (GnRH) D-Ser(TBU)6-EA10-LHRH (Buserelin) and human menopausal gonadotrophins (HMG) for ovarian stimulation for in-vitro fertilization and gamete intra-Fallopian transfer was evaluated during 84 cycles. All women selected for this therapy had previously failed stimulations with clomiphene citrate/HMG. The GnRHa prevented spontaneous luteinizing hormone surges and premature luteinization in all patients. After addition of the agonist to HMG, the cancellation rate dropped from 17 to 7% and improved the results in 72.6% of the cycles. Twenty-six per cent of the started cycles resulted in a pregnancy. Eighteen healthy children were born at term.
- Publication
Human Reproduction, 1988, Vol 3, Issue suppl_2, p35
- ISSN
0268-1161
- Publication type
Article