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- Title
Letter to editor: Serum concentration–guided intravenous magnesium sulfate administration for neuroprotection in patients with aneurysmal subarachnoid hemorrhage: A retrospective evaluation of a 12-year single-center experience.
- Authors
Sohail, Kainat; Zaidi, Syeda Mahrukh Fatima
- Abstract
This critique examines a 12-year retrospective study on serum magnesium concentration-guided administration of magnesium sulfate in 548 patients with aneurysmal subarachnoid hemorrhage (aSAH). The study reported that maintaining serum magnesium levels between 2 and 2.5 mmol/L reduced rates of delayed cerebral infarction and improved clinical outcomes. However, limitations due to its retrospective nature, single-center design, and unequal treatment group sizes may affect generalizability. Future multicentric randomized controlled trials are recommended to validate these findings and refine magnesium dosing strategies for aSAH treatment.
- Subjects
SUBARACHNOID hemorrhage; MAGNESIUM sulfate; CEREBRAL infarction; MAGNESIUM; TREATMENT effectiveness
- Publication
Neurosurgical Review, 2024, Vol 47, Issue 1, p1
- ISSN
0344-5607
- Publication type
Article
- DOI
10.1007/s10143-024-02431-y