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- Title
Envisioning the future of early anticancer drug development.
- Authors
Yap, Timothy A.; Sandhu, Shahneen K.; Workman, Paul; de Bono, Johann S.
- Abstract
The development of novel molecularly targeted cancer therapeutics remains slow and expensive with many late-stage failures. There is an urgent need to accelerate this process by improving early clinical anticancer drug evaluation through modern and rational trial designs that incorporate predictive, pharmacokinetic, pharmacodynamic, pharmacogenomic and intermediate end-point biomarkers. In this article, we discuss current approaches and propose strategies that will potentially maximize benefit to patients and expedite the regulatory approvals of new anticancer drugs.
- Subjects
ANTINEOPLASTIC agents; DRUG development; CANCER treatment; PHARMACOKINETICS; PHARMACODYNAMICS; PHARMACOGENOMICS
- Publication
Nature Reviews Cancer, 2010, Vol 10, Issue 7, p514
- ISSN
1474-175X
- Publication type
research
- DOI
10.1038/nrc2870