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- Title
The histopathological and stereological assessment of the effect of topically administered leptin on cerebral vasospasm in an experimental subarachnoid hemorrhage model.
- Authors
DEMİREL, Cem; ÇOKLUK, Cengiz; AKSOY, Abdurrahman; AYDIN, Kerameddin; ÖNGER, Mehmet Emin; KURUOĞLU, Enis; MARANGOZ, Abdullah Hilmi; DENİZ, Ömür Gülsüm; KAPLAN, Süleyman
- Abstract
Background/aim: Cerebral vasospasm is a term that refers to prolonged, slowly progressing but reversible pathological narrowing of cerebral arteries occurring several days after subarachnoid hemorrhage (SAH), usually accompanied by a decrease in perfusion distal to the affected artery. Leptin is an endogenous polypeptide hormone that can be carried freely and bound to protein in the blood. Materials and methods: We investigated the superiority of topical application of leptin that may make a contribution to the development of new treatment modalities for unconscious patients in brain injury intensive care units and its preventive effect, which is considered to have multifactorial pathogenesis on cerebral vasospasm occurring after SAH via stereological studies of the basilar artery. Results: When mean serum leptin levels of the groups were compared, statistically significant differences were observed between the control and topical leptin-treated groups in favor of the treated groups with respect to serum leptin levels (P < 0.05). In the topical leptin-applied group, a significant difference in favor of vasodilatation was observed in the measurements of the basilar artery luminal area (P < 0.05). Conclusion: In accordance with the results, the topical administration of leptin can be used in the prevention of vasospasm, especially in unconscious patients with subarachnoid hemorrhage.
- Subjects
HISTOPATHOLOGY; STEREOLOGY; LEPTIN; CEREBRAL vasospasm; SUBARACHNOID hemorrhage; THERAPEUTICS
- Publication
Turkish Journal of Medical Sciences, 2017, Vol 47, Issue 5, p1602
- ISSN
1300-0144
- Publication type
Article
- DOI
10.3906/sag-1507-110