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- Title
PRENATAL EXPOSURE TO NICOTINE: the effect of dietary supplements on the levels of IL-1a, IL-6a and TNFa expression in yhe brain, lung and placenta of rats.
- Authors
Pintican, Daniela; Strilciuc, Ş.; Mihu, D.
- Abstract
Introduction: Prenatal exposure to nicotine is a well-known risk factor for adverse consequences during pregnancy, including premature birth. Moreover, some studies have shown that smoking during pregnancy is associated with an increased risk of intrauterine infection and an altered inflammatory profile. The aim of this study was to investigate the effects of dietary supplementation after nicotine exposure measured by cytokine levels in brain, lung and placenta. Materials and methods: The quasi-experimental and cross-sectional study was performed on rats that were subjected to perigestational exposure to nicotine, vitamins and minerals. The rats (n=30) were divided into 3 groups: control group, nicotine exposure group, and nicotine exposure with dietary supplements supplementation group. We collected brain, lung and placenta tissue homogenates from each subject and determined the level of Interleukin-1 alpha (IL-1 alpha), Interleukin-2 (IL-2) and tumor necrosis factor alpha (TNF alpha). Cytokine levels were comparatively analysed to determine differences between them using means comparison and correlation tests. Results: There was an increase in IL-1a, IL-6 and TNF alpha levels in brain, lung and placental homogenates in the nicotine exposure group compared to the control group. The dietary supplements (Se and vitamin E) were associated with a decrease in protein levels of brain homogenates (IL-1a and IL-6), lung (IL-6 and TNF-a) and placenta (IL-1a, IL-6) (p<0,001). Discussion: All study groups exposed to nicotine had increased levels of cytokine. Perinatal administration of dietary supplements was associated with a decrease in the level of IL-6 for brain, lung and placenta homogenates. Further studies are needed to determine the causal interactions between Se, vitamin E and nicotine.
- Subjects
NICOTINE; PREGNANCY complications; TUMOR necrosis factors; INTERLEUKIN-2; CYTOKINES; DIETARY supplements
- Publication
Obstetrică şi Ginecologie, 2017, Vol 65, Issue 4, p211
- ISSN
1220-5532
- Publication type
Article