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- Title
Cognitive and mental health trajectories of COVID-19: Role of hospitalisation and long- COVID symptoms.
- Authors
Vakani, Krupa; Ratto, Martina; Sandford-James, Anna; Antonova, Elena; Kumari, Veena
- Abstract
Background. There is considerable evidence of cognitive impairment post COVID-19, especially in individuals with long-COVID symptoms, but limited research objectively evaluating whether such impairment attenuates or resolves over time, especially in young and middle-aged adults. Methods. Follow-up assessments (T2) of cognitive function (processing speed, attention, working memory, executive function, memory) and mental health were conducted in 138 adults (18-69 years) who had been assessed 6 months earlier (T1). Of these, 88 had a confirmed history of COVID-19 at T1 assessment (=20 days post-diagnosis) and were also followed-up on COVID-19-related symptoms (acute and long-COVID); 50 adults had no known COVID-19 history at any point up to their T2 assessment. Results. From T1 to T2, a trend-level improvement occurred in intra-individual variability in processing speed in theCOVID, relative to the non-COVIDgroup. However, longer response/task completion times persisted in participantswithCOVID-19-related hospitalisation relative to those without COVID-19-related hospitalisation and non-COVID controls. There was a significant reduction in long-COVID symptom load, which correlated with improved executive function in non-hospitalised COVID-19 participants. The COVID group continued to self-report poorer mental health, irrespective of hospitalisation history, relative to non-COVID group. Conclusions. Although some cognitive improvement has occurred over a 6-month period in young and middle-aged COVID-19 survivors, cognitive impairment persists in those with a history of COVID-19-related hospitalisation and/or long-COVID symptoms. Continuous follow-up assessments are required to determine whether cognitive function improves or possibly worsens, over time in hospitalised and long-COVID participants.
- Subjects
COGNITIVE processing speed; POST-acute COVID-19 syndrome; MENTAL health; COVID-19; MIDDLE-aged persons; VARIABILITY (Psychometrics)
- Publication
European Psychiatry, 2024, Vol 67, Issue 1, p1
- ISSN
0924-9338
- Publication type
Article
- DOI
10.1192/j.eurpsy.2024.7