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- Title
A dataset of definitive endoderm and hepatocyte differentiations from human induced pluripotent stem cells.
- Authors
Tanaka, Yuki; Furuhata, Erina; Maeda, Shiori; Kishima, Mami; Suzuki, Harukazu; Suzuki, Takahiro
- Abstract
Hepatocytes are a major parenchymal cell type in the liver and play an essential role in liver function. Hepatocyte-like cells can be differentiated in vitro from induced pluripotent stem cells (iPSCs) via definitive endoderm (DE)-like cells and hepatoblast-like cells. Here, we explored the in vitro differentiation time-course of hepatocyte-like cells. We performed methylome and transcriptome analyses for hepatocyte-like cell differentiation. We also analyzed DE-like cell differentiation by methylome, transcriptome, chromatin accessibility, and GATA6 binding profiles, using finer time-course samples. In this manuscript, we provide a detailed description of the dataset and the technical validations. Our data may be valuable for the analysis of the molecular mechanisms underlying hepatocyte and DE differentiations.
- Subjects
PLURIPOTENT stem cells; INDUCED pluripotent stem cells; ENDODERM; CELL differentiation; LIVER cells; CELL analysis
- Publication
Scientific Data, 2023, Vol 10, Issue 1, p1
- ISSN
2052-4463
- Publication type
Article
- DOI
10.1038/s41597-023-02001-9