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- Title
Transport and Bioavailability Studies of Astragaloside IV, an Active Ingredient inRadix Astragali.
- Authors
Gu, Yongchuan; Wang, Guangji; Pan, Guoyu; Fawcett, J. Paul; A., Jiye; Sun, Jianguo
- Abstract
Astragaloside IV is an important constituent ofRadix Astragali, a herbal remedy widely used in traditional Chinese medicine.Radix Astragaliis administered orally but little is known about the transport properties and bioavailability of astragaloside IV. In this paper we report studies of the absorption of astragaloside IV in the perfused rat intestinal model, transport and uptake in Caco-2 cell monolayers andin vivobioavailability in rat after an oral dose. In the perfused rat intestinal model, absorption of astragaloside IV was low from an aqueous solution but was significantly higher from a solution ofRadix Astragali. Absorption was not affected by bile duct ligation. Transport through Caco-2 cells gave a very low permeability value (meanPapp of 6.7±1.0×10−8 cm/sec.) and uptake was unaffected by P-glycoprotein inhibitors. The absolute bioavailability of astragaloside IV in rat was 2.2%. The correlation between low permeabilityin vitroand poor bioavailabilityin vivoindicatesin vitroabsorption studies are useful in the evaluation of traditional Chinese medicines.
- Subjects
DRUG administration; DRUG therapy; ABSORPTION; TOXICOLOGY; PHARMACOLOGY; MEDICAL sciences
- Publication
Basic & Clinical Pharmacology & Toxicology, 2004, Vol 95, Issue 6, p295
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/j.1742-7843.2004.t01-1-pto950508.x