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- Title
Chemokines, chemokine receptors and hematopoiesis.
- Authors
Youn, Byung-S.; Mantel, Charlie; Broxmeyer, Hal E.
- Abstract
Hematopoieses during steady state conditions is regulated and finely tuned by a network of cytokines and their effects on hematopietic stem and progenitor cells and on accessory cells that influence the stem and progenito cells. Amongst the numerous cytokines implicated in this regulation are members of the CC, CXC and C family of chemokines. Twenty-five chemokine members have been demonstrated to have the capacity to suppress the proliferation of myeloid progenitors cells. Three chemokines have been implicated in the chemotaxis of these stem and progenitor cells, and one has been linked to the survival after growth factors withdrawal. This review focuses on the proliferation-suppressing, chemotaxis-induced, and cell survival effects of different chemokine family members on myeloid progenitor cells. This is placed in the context of what we know and don't know about the intracellular signaling events mediating these effects. This information and what is yet to be learned in this area could have important clinical implications for treatment of disease.
- Subjects
CHEMOKINES; HEMATOPOIESIS
- Publication
Immunological Reviews, 2000, Vol 177, Issue 1, p150
- ISSN
0105-2896
- Publication type
Article
- DOI
10.1034/j.1600-065x.2000.17701.x