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- Title
SARS-CoV-2 Variants Identification: Overview of Molecular Existing Methods.
- Authors
Berno, Giulia; Fabeni, Lavinia; Matusali, Giulia; Gruber, Cesare Ernesto Maria; Rueca, Martina; Giombini, Emanuela; Garbuglia, Anna Rosa
- Abstract
Since the beginning of COVID-19 pandemic the Real Time sharing of genome sequences of circulating virus supported the diagnostics and surveillance of SARS-CoV-2 and its transmission dynamics. SARS-CoV-2 straightaway showed its tendency to mutate and adapt to the host, culminating in the emergence of variants; so it immediately became of crucial importance to be able to detect them quickly but also to be able to monitor in depth the changes on the whole genome to early identify the new possibly emerging variants. In this scenario, this manuscript aims to provide an overview of the existing methods for the identification of SARS-CoV-2 variants (from rapid method based on identification of one or more specific mutations to Whole Genome sequencing approach-WGS), taking into account limitations, advantages and applications of them in the field of diagnosis and surveillance of SARS-CoV-2.
- Publication
Pathogens, 2022, Vol 11, Issue 9, pN.PAG
- ISSN
2076-0817
- Publication type
Article
- DOI
10.3390/pathogens11091058