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- Title
复方黄柏液负压滴灌治疗对糖尿病足感染创面及相关炎性因子的影响.
- Authors
闫程程; 鞠上; 曹欣; 杨博华; 高瑜; 张晓福; 王宁; 连晓彤; 张素明; 张杰
- Abstract
Objective To research the clinical efficacy of negative-pressure wound therapy with instillation of FufangHuangbaiye on diabetic foot infection wound and to observe its influence on related inflammatory factors. Methods 120 patients with diabetic foot were enrolled in this study, who had ever hospitalized in the department of vascular diseases, Dongzhimen hospital, Beijing University of Chinese Medicine from December 2015 to January 2018. The patients were divided into experimental group (60 cases) and control group (60 cases) according to the random number table method. The patients in experimental group were treated with negative-pressure wound therapy with instillation of Fufang-Huangbaiye, meanwhile those in control group were treated with negative pressure wound therapy with instillation of normal saline. After 2 weeks and 4 weeks, the wound surface area, serum procalcitonin (PCT), interleukin-6 (IL-6), C-reactive protein (CRP) and local symptom score of two groups, as well as secretion culture of wounds were analyzed. Variance analysis was used to compare data difference in each group, t test or rank sum test were used to compare data difference between two groups. Results (1) Basel diabetic course, glycated hemoglobin A1c, wounds area, etc: There was no significance between two groups (all P>0.05). (2) Wound area and symptom score: After 2 weeks of treatment, the wound area and the symptom score in two groups were both reduced. After 4 weeks of treatment, the wound area reduction and symptom score in experimental group were better than those in control group [(2.3±2.0) vs (4.4±2.9) cm2, (5±3) vs (7±3) score, t=4.544, 3.321 respectively, both P<0.001]. (3) Related inflammatory factors: after 2 weeks of treatment, the levels of serum PCT, CRP and IL-6 in the two groups both decreased (t=2.282-16.745, all P< 0.001), but lower in experimental group than those in control group (t=2.867, 4.110, 3.241, respectively, all P<0.05). After 4 weeks, the level of PCT, CRP and IL-6 in two groups further decreased compared with those in the treatment for 2 weeks, however without significant difference between two groups (all P>0.05). (4) Bacteriological changes: after 2 weeks of treatment, the positive rate of bacterial culture in experimental group and control group decreased from 100% to 31.67%(19/60) and 66.67%(40/60), respectively (c2= 100.022, 37.162, both P<0.001), with statistically significance between two groups (c2=23.122, P<0.001). After 4 weeks of treatment, the positive rate of bacterial culture in 2 groups were 21.67%(13/60) and 55.00% (33/60) respectively, without significant difference compared with that after 2 weeks treatment (P>0.05), but much lower in experimental group than that in control group (c2=21.624, P<0.001). Conclusion Negative-pressure wound therapy with instillation of FufangHuangbaiye can control diabetic foot wound infection, promote wound healing, and improve clinical symptoms. Its effect is better than negative pressure wound therapy with instillation of normal saline.
- Subjects
TREATMENT of diabetic foot; TREATMENT effectiveness; DIABETIC foot; TREATMENT of vascular diseases; C-reactive protein; GLYCOSYLATED hemoglobin; PATIENTS; THERAPEUTICS
- Publication
Chinese Journal of Diabetes Mellitus, 2018, Vol 10, Issue 7, p460
- ISSN
1674-5809
- Publication type
Article
- DOI
10.3760/cma.j.issn.1674-5809.2018.07.005