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- Title
Evaluation of the brachial artery endothelial function in chronic alcohol consumption among males by high-frequency ultrasonography.
- Authors
Luo, Runlan; Shen, Jiaqi; Zhou, Qiao; Liu, Yue; Li, Guangsen
- Abstract
Objective There is evidence suggesting that different volumes of chronic alcohol consumption have different effects on the endothelium. Therefore, using high-frequency ultrasonography, we evaluate the effects of the different volume and duration of alcohol intake on brachial artery endothelial function in chronic drinkers. Methods Ninety-two male chronic episodic alcoholics were grouped by alcohol intake amount and duration: mild (group B, n=30); ≤90 mg ethanol daily, 3-5 days/wk for 5-8 years; moderate (group C, n=30); 90-150 mg ethanol daily, 3-5 days/wk for 9-20 years; and severe (group D, n=32); ≥150 mg ethanol daily, 6-7 days/wk for more than 10 years. Thirty male nondrinkers were recruited as the control group A. High-frequency ultrasonography was used to measure brachial artery diameter during rest, during reactive hyperemia and following the administration of nitroglycerin. Endothelial-dependent brachial artery flow-mediated dilatation ( FMD) and endothelial-independent brachial artery nitrate-mediated dilatation ( NMD) were calculated. Results Flow-mediated dilatation values for group C and D were significantly lower than those for group A and B ( VC=7.63±0.22, VD=5.85±0.23 vs VA=13.35±0.35, VB=12.81±0.36, P<.01). The FMD of group D was significantly lower than that of group C ( P<.01). Meanwhile, the NMD of group D was significantly lower than that of the other groups ( VD=17.33±6.21 vs VA=25.35±7.42, VB=24.52±8.30, VC=23.35±7.27, P<.01). Conclusions Chronic moderate-to-heavy alcohol consumption caused endothelial dysfunction, even damaging vascular smooth muscle cells in cases of heavy alcohol consumption, while abstinence and chronic mild alcoholics caused no effect on endothelial function.
- Subjects
CHINA; COMPLICATIONS of alcoholism; ENDOTHELIUM physiology; ACADEMIC medical centers; PEOPLE with alcoholism; ALCOHOLISM; ELECTROCARDIOGRAPHY; ENDOTHELIUM; HYPEREMIA; MEN'S health; NITRATES; NITROGLYCERIN; PROBABILITY theory; SMOOTH muscle; STATISTICS; DATA analysis; BRACHIAL artery; DATA analysis software; DESCRIPTIVE statistics; ONE-way analysis of variance
- Publication
Echocardiography, 2017, Vol 34, Issue 2, p226
- ISSN
0742-2822
- Publication type
Article
- DOI
10.1111/echo.13432