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- Title
Bone neo-formation and mineral degradation of 4Bone.<sup>®</sup> Part I: material characterization and SEM study in critical size defects in rabbits.
- Authors
Maté Sánchez de Val, José E.; Calvo Guirado, José Luis; Delgado Ruiz, Rafael A.; Gómez Moreno, Gerardo; Ramírez Fernández, Maria P.; Romanos, Georgios E.
- Abstract
Objective This study reports the characterization process and in vivo application of a new high-porosity biphasic calcium phosphate (4Bone ® - HA 60%/β- TCP 40%) inserted into the critical size defect of a rabbit tibiae. Material and methods Two critical size defects of 6 mm diameter were created in each tibia of 15 New Zealand rabbits, and a total of 60 defects were divided into a test group filled with 4Bone ® ( n = 30) and a control group ( n = 30). The material and the implants were characterized by scanning electron microscope ( SEM) fitted with energy-dispersive X-ray spectroscopy ( EDX). Results The biomaterial's grain size decreased progressively with the graft integration process over the 60-day study period. Element analysis revealed increased percentages of Ca/P (2.86 ± 0.32 vs. 1.97 ± 0.59) in new bone and at the interface ( P < 0.05). Element mapping showed that Ca and P were concentrated in the medullary and cortical zones in the test group but were concentrated only in cortical zones in the control group. Conclusions Critical size defects in a rabbit tibia model can be sealed using this highly porous biphasic calcium phosphate; it supports new bone formation, creates a bridge between defect borders, and facilitates bone in growth
- Subjects
BIOMATERIALS; GUIDED tissue regeneration; LABORATORY rabbits; CALCIUM phosphate; POROSITY; TIBIA; SCANNING electron microscopy; ENERGY dispersive X-ray spectroscopy
- Publication
Clinical Oral Implants Research, 2015, Vol 26, Issue 10, p1165
- ISSN
0905-7161
- Publication type
Article
- DOI
10.1111/clr.12420