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- Title
ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth.
- Authors
Gilbert, Christopher J.; Longenecker, Jacob Z.; Accornero, Federica
- Abstract
Simple Summary: Understanding how cardiac cells respond to external stimuli is essential for developing interventions that mitigate pathologies of the heart. Therefore, in this review, we summarize critical knowledge related to a key molecular pathway that mediates cellular responses. Integration of cellular responses to extracellular cues is essential for cell survival and adaptation to stress. Extracellular signal-regulated kinase (ERK) 1 and 2 serve an evolutionarily conserved role for intracellular signal transduction that proved critical for cardiomyocyte homeostasis and cardiac stress responses. Considering the importance of ERK1/2 in the heart, understanding how these kinases operate in both normal and disease states is critical. Here, we review the complexity of upstream and downstream signals that govern ERK1/2-dependent regulation of cardiac structure and function. Particular emphasis is given to cardiomyocyte hypertrophy as an outcome of ERK1/2 activation regulation in the heart.
- Subjects
CELL survival; HOMEOSTASIS; HEART cells; DISEASE progression; INTEGRATORS
- Publication
Biology (2079-7737), 2021, Vol 10, Issue 4, p346
- ISSN
2079-7737
- Publication type
Article
- DOI
10.3390/biology10040346