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- Title
Seroreactivity to 19.5-kDa Antigen in Combination with Absence of Seroreactivity to 35-kDa Antigen is Associated with an Increased Risk of Gastric Adenocarcinoma.
- Authors
Chua, Tju Siang; Fock, Kwong Ming; Chan, Yiong Huak; Dhamodaran, Subbiah; Sim, Chee Seng; Ng, Tay Meng; Teo, Eng Kiong
- Abstract
Abstract Background. Only a minority of those infected with Helicobacter pylori will develop gastric cancer. Stratification of H. pylori strains based on carcinogenic potential will provide a basis for selective surveillance and eradication therapy. We studied the anti-H. pylori antibody profile in Asian patients with gastric adenocarcinoma to identify any H. pylori antigen that may be associated with an increased or decreased risk of gastric carcinoma. Patients and Methods. A case-control study comparing the seroprevalence of antibodies with various H. pylori antigens in Singaporeans with gastric adenocarcinoma and the normal Singaporean population was carried out using both conventional immunoglobulin (Ig) G enzyme-linked immunosorbent assay (ELISA) and Western blot immunoassay. Results. The seroprevalence among 44 gastric adenocarcinoma cases (70.5% males, mean age 66.7 ± 13.5 years) and 261 controls (49.8% males, mean age 61.5 ± 4.1 years) was 90.9% vs. 50.2% by IgG ELISA. In the H. pylori- positive male population, those suffering from gastric adenocarcinoma had significantly lower seroreactivity to the 35-kDa antigen compared with asymptomatic controls (p = .0198, OR = 3.79, 95% CI 1.24–11.61). Seropositivity to the 19.5 kDa antigen was also found to be associated with the presence of gastric adenocarcinoma in Singaporean males (p = .022, OR = 4.17, 95% CI 1.22–14.28). A ‘high-risk’ phenotype consisting of absence of a band at 35-kDa in combination with the presence of a band at 19.5-kDa was significantly associated with the presence of gastric adenocarcinoma (p = .002, OR = 3.7, 95% CI 1.6–8.6). Conclusions. Stratification of H. pylori strains based on their potential for carcinogenesis, such as those strains that are seropositive for the 19.5 kDa antigen and seronegative for the 35-kDa antigen, may provide a basis for selective eradication of H. pylori infection and future vaccine development.
- Subjects
ASIA; STOMACH cancer; CANCER risk factors; HELICOBACTER pylori; HUMAN immunogenetics
- Publication
Helicobacter, 2002, Vol 7, Issue 4, p257
- ISSN
1083-4389
- Publication type
Article
- DOI
10.1046/j.1523-5378.2002.00089.x