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- Title
Dupilumab‐induced psoriasiform dermatitis in two pediatric cardiac transplant patients.
- Authors
Lockard, Trevor; Mullen, Sarah A.; Lee, Erica B.; Niebur, Hana; Harter, Nicole
- Abstract
Dupilumab is an interleukin‐4 receptor antagonist important in the treatment of refractory atopic dermatitis (AD), particularly among pediatric patients. Two boys with a history of AD and cardiac transplant who developed psoriasiform dermatitis in response to dupilumab therapy are reported. These patients paradoxically developed an immune‐mediated adverse drug reaction despite taking systemic immunosuppressive agents. While the literature suggests possible pathomechanisms for psoriasiform dermatitis despite immunosuppression, further research is necessary to better characterize this unique and unexpected phenomenon.
- Subjects
HEART transplantation; DRUG side effects; SKIN inflammation; CARDIAC patients; DRUG eruptions
- Publication
Pediatric Dermatology, 2024, Vol 41, Issue 3, p508
- ISSN
0736-8046
- Publication type
Article
- DOI
10.1111/pde.15497