We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Direct effects of corticotrophin-releasing hormone on stimulated growth hormone secretion.
- Authors
Raza, Jamal; Massoud, Ahmed F.; Hindmarsh, Peter C.; Robinson, Iain C. A. F.; Brook, Charles G. D.
- Abstract
OBJECTIVE This study evaluated the effect of corticotrophin-releasing hormone (CRH) on growth hormone releasing hormone (GHRH)-stimulated growth hormone (GH) release in man. DESIGN Six healthy adult volunteers (age 20–35 years) were studied. On different occasions they each received an intravenous bolus of saline, CRH(1–41) (100 μg), adrenocorticotrophic hormone (ACTH) [Synacthen (500 ng/m2 )] or hydrocortisone (50 mg), followed 30 minutes later by an intravenous bolus of either GHRH-(1–29)-NH2 (1.0 μg/kg) or saline. MEASUREMENT Serum GH concentrations were measured using an immunoradiometric assay, and cortisol concentrations were measured by commercial radioimmunoassay. TSH concentrations were measured using a solid phase immunoradiometric assay kit. RESULTS Pretreatment with CRH(1–41) attenuated the GH response to GHRH [saline/GHRH-(1–29)-NH2 20.2 ± 6.2 mU/l; CRH(1–41)/GHRH-(1–29)-NH2 10.9 ± 2.8 mU/l (P = 0.01)]. This effect was not due to the rise in ACTH or cortisol induced by CRH(1–41), since pretreatment with either ACTH or hydrocortisone significantly augmented the GH response to GHRH-(1–29)-NH2 in the same subjects [ACTH/GHRH-(1–29)-NH2 30.3 ± 8.8 mU/l (P = 0.01); hydrocortisone/GHRH-(1–29)-NH2 36.4 ± 11.2 mU/l (P = 0.02)]. CONCLUSION Our data suggest that the inhibitory effect of CRH(1–41) on GHRH-(1–29)-NH2 -induced GH release is not a result of ACTH or cortisol release but reflects a direct action of CRH on GH secretion, possibly via stimulation of somatostatin release. The acute rise in GH following glucocorticoid administration could be explained in part by a rapid suppression of endogenous CRH.
- Subjects
CORTICOTROPIN releasing hormone; GROWTH hormone releasing factor; SOMATOTROPIN
- Publication
Clinical Endocrinology, 1998, Vol 48, Issue 2, p217
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1046/j.1365-2265.1998.3821204.x