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- Title
SOLID DISPERSION: AN EVOLUTIONARY PLAN FOR SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS.
- Authors
Patil, Pratik D.; Bakliwal, Sunil R.; Gujarathi, Nayan A.; Rane, Bhushan R.; Pawar, S. P.
- Abstract
Although marvelous advancement in drug delivery, oral route remains the preferred route for the administration due to higher levels of patient compliance. It can be a complicated and unproductive means of delivery for water-insoluble drugs with high permeability or Class II drugs in FDA's Biopharmaceutical Classification System (BCS). Such drugs in general exhibit dissolution rate limited absorption resulting in poor bioavailability when delivering via the oral route. Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. The experience with solid dispersions over the last 20-30 years indicates that this is a very productive approach to improving the release rate and oral bioavailability of poorly water soluble drugs and the availability of a wide variety of polymers that are themselves poorly soluble or which swell under aqueous conditions suggests that solid dispersions have remarkable potential in the area of controlled release dosage forms. This strategy has proven to improve the bioavailability by dispersing the hydrophobic drug as very fine particles within hydrophilic matrix that results in increased solubility with increased surface area available for dissolution. The expansion of solid dispersions as a practically viable method to boost bioavailability of poorly water-soluble drugs and overcame the limitations of previous approaches such as salt formation, solubalization by cosolvents, and particle size reduction. Being versatile in their application, solid dispersions can form the basis of products applied for various routes of administration and for various dosage forms. The focus of this review article is on advantages, disadvantages. Also covers brief preface of solid dispersion highlighting various approaches for their preparation, technology involved, selection of carriers and methods of characterization.
- Subjects
SOLUBILITY; DRUG administration; BIOAVAILABILITY; BIOPHARMACEUTICAL research; POLYMER research; ORAL drug administration
- Publication
Pharma Science Monitor, 2013, Vol 4, Issue 1, p3683
- ISSN
0976-9242
- Publication type
Article