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- Title
Deletion of 11q23 is a highly specific nonrandom secondary genetic abnormality of ETV6/RUNX1-rearranged childhood acute lymphoblastic leukemia.
- Authors
Attarbaschi, A.; Mann, G.; Strehl, S.; König, M.; Steiner, M.; Jeitler, V.; Lion, Th.; Dworzak, M. N.; Gadner, H.; Haas, O. A.
- Abstract
The authors discusses their finding that the deletion of 11q23 is a nonrandom and highly specific secondary genetic abnormality in ETV6/RUNX1 B-cell acute lymphoblastic leukemia (ALL) rather than a disease-relevant primary abnormality. Chromosome band 11q23 is the site of the mixed lineage leukemia gene that is most often disrupted in 11q23 abnormalities of various hematological neoplasms. Genetic abnormalities involving the 11q23/mixed lineage leukemia region account for about five to ten percent of childhood ALL.
- Subjects
LYMPHOBLASTIC leukemia in children; LYMPHOBLASTIC leukemia; HUMAN abnormalities; B cell lymphoma; CHROMOSOMES
- Publication
Leukemia (08876924), 2007, Vol 21, Issue 3, p584
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/sj.leu.2404507