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- Title
Immunoglobulin κ gene rearrangements between the κ deleting element and Jκ recombination signal sequences in acute lymphoblastic leukemia and normal hematopoiesis.
- Authors
Seriu, T; Hansen-Hagge, T E; Stark, Y; Bartram, C R
- Abstract
The κ deleting element (κDE) located 24 kb downstream of the Cκ gene segment mediates the deletion of Cκ and the Jκ-Cκ Intron enhancer, which results in allelic exclusion of the immunoglobulin κ light chain locus. We here report that the κDE can recombine to each recombination signal sequence (RSS) flanking Jκ1 to Jκ5 in normal hematopoiesis. Moreover, usage of the JκRSS-κDE junctional sequence allows the detection of minimal residual disease in acute lymphoblastic leukemia.
- Subjects
IMMUNOGLOBULINS; LYMPHOBLASTIC leukemia
- Publication
Leukemia (08876924), 2000, Vol 14, Issue 4, p671
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/sj.leu.2401745