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- Title
Bicarbonate-binding catalysis for the enantioselective desymmetrization of keto sulfonium salts.
- Authors
Alemán, José; Humbrías-Martín, Jorge; del Río-Rodríguez, Roberto; Aguilar-Galindo, Fernando; Díaz-Tendero, Sergio; Fernández-Salas, Jose A.
- Abstract
Herein, an enantioselective desymmetrization of cyclic keto sulfonium salts through enantioselective deprotonation/ring opening process by anion-binding catalysis is presented. We report a squaramide/HCO3- complex as catalytic active species which is able to stereo-differentiate two enantiomeric protons, triggering the ring opening event taking advantage of the great tendency of sulfonium salts to act as leaving groups. Thus, this desymmetrization methodology give rise to β-methylsulfenylated sulfa-Michael addition type products with excellent yields and very good enantioselectivities. The bifunctional organocatalyst has been demonstrated to be capable of activating simultaneously the base and the keto sulfonium salt by DFT calculations and experimental proofs. Although anion-binding processes are well-known for their crucial role in molecular recognition, this type of phenomenon has only recently been utilized for catalysis. Here, the authors present an enantioselective desymmetrization of cyclic keto sulfonium salts through enantioselective deprotonation/ring opening process by anion-binding catalysis.
- Subjects
ENANTIOSELECTIVE catalysis; SALT; SALTS; MOLECULAR recognition; CATALYSIS
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-48832-x