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- Title
TAZ deficiency exacerbates psoriatic pathogenesis by increasing the histamine-releasing factor.
- Authors
Song, Jiseo; Kim, Hyo Kyeong; Cho, Hyunsoo; Yoon, Suh Jin; Lim, Jihae; Lee, Kyunglim; Hwang, Eun Sook
- Abstract
Background: Transcriptional coactivator with PDZ-biding motif (TAZ) is widely expressed in most tissues and interacts with several transcription factors to regulate cell proliferation, differentiation, and death, thereby influencing organ development and size control. However, very little is known about the function of TAZ in the immune system and its association with inflammatory skin diseases, so we investigated the role of TAZ in the pathogenesis of psoriasis. Results: Interestingly, TAZ was expressed in mast cells associated, particularly in lysosomes, and co-localized with histamine-releasing factor (HRF). TAZ deficiency promoted mast cell maturation and increased HRF expression and secretion by mast cells. The upregulation of HRF in TAZ deficiency was not due to increased transcription but to protein stabilization, and TAZ restoration into TAZ-deficient cells reduced HRF protein. Interestingly, imiquimod (IMQ)-induced psoriasis, in which HRF serves as a major pro-inflammatory factor, was more severe in TAZ KO mice than in WT control. HRF expression and secretion were increased by IMQ treatment and were more pronounced in TAZ KO mice treated with IMQ. Conclusions: Thus, as HRF expression was stabilized in TAZ KO mice, psoriatic pathogenesis progressed more rapidly, indicating that TAZ plays an important role in preventing psoriasis by regulating HRF protein stability. Highlights: HRF is expressed in lysosomes and associated with TAZ expression. HRF expression is increased in TAZ-deficient immune cells. HRF protein stability is controlled by TAZ, resulting in stabilized HRF in TAZ deficiency. TAZ deficiency promotes susceptibility to IMQ-induced psoriasis, leading to exacerbated psoriatic inflammation.
- Subjects
MAST cells; MORPHOGENESIS; PATHOGENESIS; TRANSCRIPTION factors; SKIN diseases; PROTEIN expression; PROTEIN stability
- Publication
Cell & Bioscience, 2024, Vol 14, Issue 1, p1
- ISSN
2045-3701
- Publication type
Article
- DOI
10.1186/s13578-024-01246-0