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- Title
Multiple Forms of Catalase From Normal Human Liver, Hepatomas and Tumor-Bearing Livers*.
- Authors
KOYAMA, SHOHEI; HATTORI, NOBU; OKAZAKI, NOBUO; OHNO, TAKANORI; KANDA, YUZO
- Abstract
Multiple forms of catalase from normal human liver, hepatomas, fetal liver and tumor-bearing livers were examined by the method of DEAE-cellulose column chromatography. In normal adult human liver, three peaks were found by addition of 0.05 M, 0.1 M and 0.2 M NaCl in 0.01 M phosphate buffer (pH 7.4), and no catalase activity was detected in the unadsorbed fraction. On the other hand, in human hepatomas, fetal liver and tumor-bearing livers, an existence of the unadsorbed catalase fraction was ascertained. It is suggested that the presence of the unadsorbed catalase on DEAE-cellulose may be ascribed to the dedifferentiated nature of liver tissues. Furthermore, no difference in molecular size between the unadsorbed catalase and the adsorbed one was confirmed by gel filtration on Sephadex G-200.
- Publication
Japanese Journal of Clinical Oncology, 1974, Vol 4, Issue 1, p47
- ISSN
0368-2811
- Publication type
Article