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- Title
Biomedical Membrane of Fish Collagen/Gellan Gum Containing Bone Graft Materials.
- Authors
Kim, Jin; Lee, Chang-Moon; Moon, Seong-Yong; Jeong, Young-IL; Kim, Chun Sung; Lee, Sook-Young
- Abstract
The development of a guided bone regeneration (GBR) membrane with non-mammalian fish collagen has the advantage of low risk for transmission of infectious diseases in tissue regeneration. In this work, a fish collagen/gellan gum and bone graft material (FC/GG-BGM) composite GBR membrane were fabricated through solution blending and casting procedures in a vacuum. The membranes were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy observation (SEM), and atomic force microscope (AFM) analyses. FT-IR results suggested that ionic interactions were formed between FC and GG both in composite powder and membranes. In vivo experiments showed that these FC/GG-BGM composite membranes could generate osteoblast minerals and promote loose bone calcification, thus accelerating bone regeneration. At 2 weeks, the defected site of rats treated with FC/GG-BGM membrane (0.377 ± 0.012 mm3) showed higher regeneration than that of rats treated with the bovine collagen membrane (0.290 ± 0.015 mm3) and control rats without membrane (0.160 ± 0.008 mm3). Compared with bovine collagen membrane, the FC/GG-BGM composite membrane displays better bone regeneration ability. Therefore, FC/GG-BGM composite membrane is suitable as a GBR membrane for bone regeneration.
- Subjects
GELLAN gum; COMPOSITE membranes (Chemistry); BONE regeneration; BONE grafting; GUIDED bone regeneration; FOURIER transform infrared spectroscopy; COLLAGEN
- Publication
Materials (1996-1944), 2022, Vol 15, Issue 8, pN.PAG
- ISSN
1996-1944
- Publication type
Article
- DOI
10.3390/ma15082954