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- Title
The prognostic impact of neutrophil to lymphocyte ratio in advanced non-small-cell lung cancer patients treated with EGFR TKI.
- Authors
Phan, Thang Thanh; Ho, Toan Trong; Nguyen, Hue Thi; Nguyen, Hang Thuy; Tran, Thu Bich; Nguyen, Son Truong
- Abstract
Purpose: To identify and clarify the roles of inflammatory markers in prognosis for advanced non-small cell lung cancer (NSCLC) patients treated with EGFR tyrosine kinase inhibitor (TKI). Patients and methods: One hundred and twelve adenocarcinoma, clinical stage IV, NSCLC patients with either EGFR exon 19 deletion (E19del) or EGFR exon 21 L858R substitution mutation (L858R) were selected for this study. The blood cell count at different stages of treatment was used to calculate the inflammatory markers. The Kaplan–Meier statistics and Cox regression model were used to test the differences of progression-free survival (PFS) between groups by the optimal cutoff point of biomarkers. Results: The median values of white blood cell (WBC), neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) in NSCLC patients tended to be reduced after 3 months treated with EGFR TKI and increased conversely when the disease develops progression (P
- Subjects
BLOOD cell count; CANCER patients; KINASE inhibitors; NON-small-cell lung carcinoma; PROGNOSIS; NEUTROPHILS; LYMPHOCYTES; LEUCOCYTES; BLOOD platelets
- Publication
International Journal of General Medicine, 2018, Vol 11, p423
- ISSN
1178-7074
- Publication type
Article
- DOI
10.2147/IJGM.S174605