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- Title
Effect of beta-sitosterol on glycogen metabolic enzyme in high-fat fed diabetic model.
- Authors
Shree, M. Kavya; Vishnupriya, V.; Ponnulakshmi, R.; Gayathri, R.; Madhan, K.; Shyamaladevi, B.; Selvaraj, J.
- Abstract
Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by insufficient insulin secretion or resistance to insulin secretion or resistance to insulin action or both. Management of DM with natural antioxidants grabs great interest of research due to its beneficiary effects. Hence, in our study, we focused to study beta-sitosterol (BS), a plant sterol found in the wheat germ, Ce, flax seeds, peanuts, soybean, and variety of medicinal plants. It has antidiabetic, hypolipedemic, anticancer, antiarthritic, and hypoprotective role. In the present study, we elucidated the effects of BS on key enzymes of carbohydrates metabolism, which has been not yet studied clearly. Objectives: The objectives of this study were to study the effects of BS on glycogen metabolic enzymes in hepatic tissue of type 2 diabetic rats by spectrometry analysis. Methodology: BS was administered orally to type-2 diabetic rats (25 mg/kg body weight) for a period of 30 days. After the treatment period, animals were anesthetized and liver from control and experimental rats dissected out and the used for the studied. Results: There was a marked decrease observed in the levels of glycogen metabolic enzymes such as glycogen phosphorylase, glycogen synthase, and glycogen concentration in the liver of the type-2 diabetic rats. However, BS treatment efficiently increased the level of antioxidant enzymes compared to diabetic group. Metformin showed a similar pattern to that of BS. Conclusion: The present finding concluded that the BS regulates glycogen metabolic enzymes in the liver, and hence, it can be used for the management of type -2 diabetes as a natural compound.
- Subjects
STREPTOZOTOCIN; CARBOHYDRATE metabolism; GLYCOGEN phosphorylase; INSULIN resistance; WHEAT germ; LIVER enzymes
- Publication
Drug Invention Today, 2019, Vol 12, Issue 5, p870
- ISSN
0975-7619
- Publication type
Article