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- Title
Influence of adrenaline containing local anesthesia on the glycemic level of patients undergoing tooth extraction.
- Authors
Hemani, K.; Bhoj, Mimansa; Ganapathy, Dhanraj M.; Mallikarjuna, Arunasree Vadaguru
- Abstract
Background: Catecholamines or stress hormones induce hemodynamic changes such as peripheral vasoconstriction, to redirect blood, and to vital organs during stress. The heart responds by increasing heart rate (HR) that makes available more blood to the vital organs marked by an increase in blood pressure (BP). The liver responds by increasing glucagon release to increase glucose levels and additionally inhibiting insulin-dependent glucose uptake by peripheral tissues, thereby inducing hyperglycemia making available more sugar for the efficient functioning of organs. Adrenaline is present in the local anesthetic solution used in dental procedures for vasoconstriction, due to its other physiological effect, it is expected to produce hyperglycemia when injected. This is in addition to the endogenous catecholamines released in response to psychological stress undergone by a normal patient in the event of an extraction. Literature on the blood glycemic level in a diabetic patient undergoing extraction has been contradictory. The present study, therefore, aims to assess the glycemic levels at different stages of extraction in healthy adult and to compare the same with diabetic patients undergoing tooth extraction under local anesthesia with adrenaline 1:80,000. Materials and Method: A total of 21 healthy and 18 controlled Type 2 diabetic patients, aged of 25-55 years, undergoing tooth extraction under local anesthesia were included in the study. 2 ml of lignocaine hydrochloride with adrenaline 1:80,000 was used as local anesthetic agent blood glucose level (BGL) which was assessed before local anesthesia, 10 min after local anesthesia and 10 min post-extraction for all patients. Results: No statistically significant difference in the mean blood glucose concentration was noticed at three different time intervals among the two groups. Conclusions: Local anesthetic solutions containing adrenaline may safely be used for dental procedures in patients with Type 2 diabetes mellitus.
- Subjects
GLYCEMIC index; LOCAL anesthesia; DENTAL extraction; ADRENALINE; TYPE 2 diabetes; BLOOD sugar
- Publication
Drug Invention Today, 2019, Vol 11, Issue 3, p725
- ISSN
0975-7619
- Publication type
Article