We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A single-blinded randomized trial to evaluate the efficacy of N-acetyl cysteine over metformin in patients with polycystic ovarian syndrome.
- Authors
Kumar, M. Ashok; George, P. Samuel Gideon; Dasari, Anoosha; Shanmugasundaram, P.
- Abstract
Objective: The objective of the study was to evaluate and compare the efficacy of metformin and N-acetyl cysteine (NAC) on clinical, hormonal, and fertility aspects in polycystic ovarian syndrome (PCOS). Materials and Methods: Through a prospective randomized study on women with a diagnosis of PCOS without any comorbidity conditions were enrolled and assigned into two groups. Group A with metformin 500 mg thrice a day and Group B with NAC 600 mg thrice a day were prescribed and duration of the treatment was fixed as 12 weeks. After the prescribed duration of treatment, the following parameters such as fasting blood glucose, fasting insulin, glucose-insulin ratio, LH, FSH, and LH/FSH ratio were measured and compared between two groups. Results and Discussion: Fifty women of each group completed the study, and it was found those age groups between 25 and 30 years are more prone to have PCOS. Among the two groups, there was a significant difference in body weight, body mass index, and clinical parameters such as FBS, fasting insulin, and hormonal parameters such as LH, FSH, oligomenorrhea, amenorrhea, and infertility got reduced and it was observed that LH/FSH ratio and glucose/insulin ratio got reduced in both the group but the difference between the two groups were insignificant. Conclusion: The present study concludes that NAC found to improves some clinical features, biochemical markers of insulin resistance and hormonal levels and long-term health of women with PCOS through improvement in peripheral insulin and fewer side effects; thus NAC can be considered as a substitute for insulin-reducing medications in the treatment of PCOS patients.
- Subjects
POLYCYSTIC ovary syndrome; ACETYLCYSTEINE; METFORMIN; CLINICAL trials; TREATMENT effectiveness; PATIENTS
- Publication
Drug Invention Today, 2018, Vol 10, Issue 2, p241
- ISSN
0975-7619
- Publication type
Article