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- Title
Narrowing the spectrum: the new frontier of precision antimicrobials.
- Authors
Paharik, Alexandra E.; Schreiber Iv, Henry L.; Spaulding, Caitlin N.; Dodson, Karen W.; Hultgren, Scott J.
- Abstract
Antibiotics have become the standard of care for bacterial infections. However, rising rates of antibioticresistant infections are outpacing the development of new antimicrobials. Broad-spectrum antibiotics also harm beneficial microbial communities inhabiting humans. To combat antibiotic resistance and protect these communities, new precision antimicrobials must be engineered to target specific pathogens.
- Subjects
ANTIBIOTICS; BACTERIAL disease treatment; DRUG resistance in microorganisms; ANTI-infective agents; DRUG development
- Publication
Genome Medicine, 2017, Vol 9, p1
- ISSN
1756-994X
- Publication type
Article
- DOI
10.1186/s13073-017-0504-3