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- Title
EFFECT OF TANNIC ACID ON GROWTH AND ACID PRODUCTION OF CANDIDA ALBICANS.
- Authors
AL BAGIEH, NASIR H.; AL BAGEAH, HAMAD N.
- Abstract
Tannic Acid or Hydrolysable Tannins are naturally occurring complex phenol-rich polymers; prevalent in a wide variety of herbs, plants and fruits. Tannic Acid's antimicrobial activity against food-borne pathogens has been recognized and it is generally considered a safe food additive. The present study was carried out to investigate the effect of Tannic acid (TA) on the growth and acid production of C. albicans. Various concentrations of TA prepared with Sabourand's dextrose broth were inoculated with C. albicans and incubated at 37°C. Growth was monitored by optical density (OD) at 560nm wavelength and measured at specific intervals over a period of 24 hours. C. albicans cells were used as a non-growing cell suspension in a buffer solution of 40mM Sodium bicarbonate (NaHCO3) and 6mM Dipotassium phosphate (K2HPO4) to which various concentrations of TA were added. Acid production was stimulated by the addition of 1% glucose. The data obtained showed that TA was fungistatic at concentrations of 10, 50, 300 and 500 µg/ml and fungicidal at 700 µg/ml. Acid production of C. albicans was inhibited at concentrations of 100, 300 and 500 µg/ml. The inhibitory activity of TA on growth and acid production of C. albicans suggests that TA could play an important role in prevention and treatment of Oral Candidosis and in reducing caries activity.
- Subjects
TANNINS; PHENOL; POLYMER research; CANDIDA albicans; CANDIDIASIS
- Publication
Pakistan Oral & Dental Journal, 2014, Vol 34, Issue 3, p405
- ISSN
1012-8700
- Publication type
Article