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- Title
Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain.
- Authors
Xiushuai Shang; Zhaofei Wang; Hairong Tao; Shang, Xiushuai; Wang, Zhaofei; Tao, Hairong
- Abstract
Osteoarthritis (OA) is the most common form of articular joint arthritis and a cause of significant morbidity. In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor-β1, mechanical loading, and adipokines) involved in OA development. Since NGF blocking is an efficient way to inhibit OA-associated pain, we summarize four categories of drugs that target NGF/tropomyosin receptor kinase A (TrkA) signaling. In addition, we discuss the future of NGF/TrkA antagonists and underline their potential for use in OA pain relief. A better understanding of the causes and treatment of OA will facilitate the development of more effective methods of OA pain management.
- Subjects
NERVE growth factor; OSTEOARTHRITIS; INTERLEUKIN-1; TRANSFORMING growth factors; ADIPOKINES; TROPOMYOSINS
- Publication
Therapeutics & Clinical Risk Management, 2017, Vol 13, p951
- ISSN
1176-6336
- Publication type
journal article
- DOI
10.2147/TCRM.S139814