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- Title
Relevance of callosal and periventricular MRI lesions to oligoclonal bands in multiple sclerosis.
- Authors
Nakashima, Ichiro; Fujihara, K.; Miyazawa, H.; Misu, T.; Fujimori, J.; Sato, S.; Itoyama, Y.
- Abstract
Objectives – To evaluate the association between callosal or periventricular lesions, and the presence of oligoclonal IgG bands (OB) or the IgG index in Japanese patients with multiple sclerosis (MS). Materials and methods – Brain magnetic resonance imaging (MRI) was studied in 34 Japanese clinically definite MS cases. Sagittal 2-mm fast fluid-attenuated inversion-recovery (FLAIR) imaging was added to the routine MRI studies. Results – Among the 34 patients, 20 (59%) were OB positive. Among the 20 patients with OB-positive MS, 17 (85%) had callosal lesions, although only two (14%) of 14 OB-negative MS patients had callosal lesions. The periventricular lesion area was significantly larger in the OB-positive patients compared with the OB-negative patients. Conclusionsv– The present study clearly demonstrated a strong association between the periventricular lesions and OB in Japanese MS. Certain OB-related immune mechanisms may contribute to the development of callosal and periventricular lesions in MS. OB may be an important factor to understand the pathomechanisms of MS lesions.
- Subjects
MULTIPLE sclerosis; MAGNETIC resonance imaging; IMMUNOGLOBULIN G; CORPUS callosum; TELENCEPHALON; BRAIN
- Publication
Acta Neurologica Scandinavica, 2006, Vol 113, Issue 2, p125
- ISSN
0001-6314
- Publication type
Article
- DOI
10.1111/j.1600-0404.2005.00552.x