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- Title
Editorial: Altered metabolic traits in gastrointestinal tract cancers.
- Authors
Parte, Seema; Pothuraju, Ramesh; Kumavath, Ranjith; Bhatia, Rakesh; Nimmakayala, Rama Krishna; Gautam, Shailendra
- Abstract
This document is an editorial published in Frontiers in Endocrinology that discusses the altered metabolic traits in gastrointestinal tract cancers. The editorial highlights the challenges in understanding and treating GI cancers, which are a leading cause of cancer-related mortality globally. It emphasizes the role of dysregulated receptor tyrosine kinases and oncogenes in disrupting metabolic pathways in tumor cells. The editorial also mentions the potential of biomarkers and therapeutic targets in improving early detection and treatment of GI cancers. The document includes reviews on colorectal cancer pathogenesis and gene set enrichments for pancreatic neuroendocrine tumors. The document provides a summary of research on the metabolic activities and irregularities in gastrointestinal (GI) tumors. It highlights the dysregulated metabolic pathways in GI tumors, including glucose and lipid metabolism, and their impact on tumor biology. The document also discusses potential therapeutic approaches, such as targeting lipid metabolism and using a combination therapy of vitexin and aspirin for GI tract cancers. It emphasizes the need for personalized cancer therapies and precision oncology to address the complexities of tumor cells, tumor-initiating stem cells, and the tumor microenvironment.
- Subjects
GASTROINTESTINAL cancer; MOLECULAR biology; GLYCOLYSIS; GASTROINTESTINAL system; PYRUVATE dehydrogenase kinase; LIFE sciences
- Publication
Frontiers in Endocrinology, 2024, p01
- ISSN
1664-2392
- Publication type
Article