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- Title
A General Cognitive Ability Factor for the UK Biobank.
- Authors
Williams, Camille Michèle; Labouret, Ghislaine; Wolfram, Tobias; Peyre, Hugo; Ramus, Franck
- Abstract
UK Biobank participants do not have a high-quality measure of intelligence or polygenic scores (PGSs) of intelligence to simultaneously examine the genetic and neural underpinnings of intelligence. We created a standardized measure of general intelligence (g factor) relative to the UK population and estimated its quality. After running a GWAS of g on UK Biobank participants with a g factor of good quality and without neuroimaging data (N = 187,288), we derived a g PGS for UK Biobank participants with neuroimaging data. For individuals with at least one cognitive test, the g factor from eight cognitive tests (N = 501,650) explained 29% of the variance in cognitive test performance. The PGS for British individuals with neuroimaging data (N = 27,174) explained 7.6% of the variance in g. We provided high-quality g factor estimates for most UK Biobank participants and g factor PGSs for UK Biobank participants with neuroimaging data.
- Subjects
UNITED Kingdom; COGNITIVE ability; COGNITIVE testing; GENOME-wide association studies; BRAIN imaging
- Publication
Behavior Genetics, 2023, Vol 53, Issue 2, p85
- ISSN
0001-8244
- Publication type
Article
- DOI
10.1007/s10519-022-10127-6