We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
EVALUATION OF COMBINED RADIATION FOR THE TREATMENT OF LAMIVUDINE AND ZIDOVUDINE VIA AOP.
- Authors
ANDRADE DE LUCENA, ALEX LEANDRO; DA ROCHA SANTANA, RAYANY MAGALI; SOARES DE OLIVEIRA, MARCOS ANDRÉ; COSTA ALMEIDA, LUCIANO; MENEZES BEZERRA DUARTE, MARTA MARIA; NAPOLEÃO, DANIELLA CARLA
- Abstract
The presence of pharmaceutical contaminants in nature is an environmental problem generating increasing concerns. Due to this, it is necessary to evaluate treatments capable of degrading these contaminants, such as the advanced oxidation processes (AOPs). In this work, the photoperoxidation and photo-Fenton AOP were applied to degrade a mixture of lamivudine and zidovudine in an aqueous medium and synthetic effluent (SE). To this end, a bench reactor (UV-C; UV-A and sunlight irradiations) was built. The AOP treatments efficiency was evaluated by ultraviolet/visible spectrophotometry. The tests involved the application of the irradiations individually and combined. The best operational conditions were [H2O2 ] of 600 mg L-1 and [Fe] of 0.5 mg L-1, for both matrices, with degradations of 90.53% and 89.32% for the photoperoxidation and photo-Fenton processes in aqueous media and 88.69% and 85.79% in SE. Kinetic studies showed a good fit for two pseudo-first-order models with R² > 0.93. Toxicity tests involving the application of lettuce, carrot, and tomato seeds showed an inhibition for the three seeds when submitted to solutions after treatment, for both matrices, this fact is corroborated by the HPLC analysis, in which the formation of small peaks was verified, suggestive of the formation of byproducts. Thus, it can be affirmed that both photo-Fenton and photoperoxidation processes efficiently degrade the drug mixture when applying UV-C radiation.
- Subjects
LAMIVUDINE; AZIDOTHYMIDINE; TOMATO seeds; LETTUCE; TOXICITY testing; CARROTS; RADIATION
- Publication
Chemical Industry & Chemical Engineering Quarterly, 2022, Vol 28, Issue 3, p179
- ISSN
1451-9372
- Publication type
Article
- DOI
10.2298/CICEQ210309029L