We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of Uveitis on Quality of Life in Adult Patients With Juvenile Idiopathic Arthritis.
- Authors
Haasnoot, Anne-Mieke J. W.; Sint Jago, Naïlah F. M.; Tekstra, Janneke; Boer, Joke H.; Sint Jago, Naïlah F M; de Boer, Joke H
- Abstract
<bold>Objective: </bold>To establish the impact of uveitis on the quality of life (QoL) in adult patients with juvenile idiopathic arthritis (JIA).<bold>Methods: </bold>Adult patients with a history of JIA, both with (n = 31) or without (n = 51) chronic anterior uveitis, were included. Their scores on 3 validated QoL questionnaires (National Eye Institute Visual Functioning Questionnaire [NEI VFQ-25], Medical Outcomes Study 36-Item Short Form health survey [SF-36], and EuroQol 5-domain questionnaire [EQ-5D]) were analyzed to find factors that could influence QoL.<bold>Results: </bold>The median overall composite score (OCS) of the NEI VFQ-25 was significantly worse in the uveitis group compared to the non-uveitis group (respectively, 83.4 [range 15.2-94.7] and 94.9 [range 46.3-100]; P < 0.001). Nearly all subscale scores were lower in patients with uveitis than in patients without uveitis (P < 0.001 for all). After adjusting for duration of arthritis, JIA subtype, arthritis onset before or after 1990, and the use of systemic immunomodulatory medication, the QoL was still worse in patients with uveitis (NEI VFQ-25 OCS regression coefficient = -11.7; P = 0.002). No significant differences were found between the groups for the SF-36 and the EQ-5D. In the total JIA group, the use of systemic medication appeared to negatively influence some general QoL scores.<bold>Conclusion: </bold>Having a history of uveitis has a substantial negative effect on the vision-related QoL in JIA in adulthood, despite good visual acuity. General QoL scores did not differ between uveitis and non-uveitis patients, but the use of systemic immunomodulatory treatment, independent of uveitis, did negatively influence general QoL scores in adult JIA patients.
- Subjects
IMMUNOLOGICAL adjuvants; AGE factors in disease; CHRONIC diseases; HEALTH status indicators; HEALTH surveys; MULTIVARIATE analysis; IRIDOCYCLITIS; QUALITY of life; QUESTIONNAIRES; REGRESSION analysis; TIME; DISEASE complications; JUVENILE idiopathic arthritis; PSYCHOLOGY; DIAGNOSIS; THERAPEUTICS
- Publication
Arthritis Care & Research, 2017, Vol 69, Issue 12, p1895
- ISSN
2151-464X
- Publication type
journal article
- DOI
10.1002/acr.23224