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- Title
<sup>125</sup>I-insulin metabolism in chronic renal failure treated by renal transplantation.
- Authors
Fuss, Michel; Bergans, Agnès; Brauman, Henri; Toussaint, Charles; Vereerstraeten, Pierre; Franckson, Marcel; Corvilain, Jacques
- Abstract
Total clearance rate (TCR), urinary clearance rate (UCR) and metabolic clearance rate (MCR) of 125l-insulin were reinsured in patients with severe chronic renal insufficiency and after renal transplantation. The methodology involved the constant infusion (11.5 ng/kg/min) of mildly, iodinated 125I-insulin (mean degree of iodination less than 0.2 atom/molecule), and the estimation of the plasma concentration of labelled insulin by chromatoelectrophoresis. MCR was decreased by about 50% in chronic renal insufficiency, treated or not by hemodialysis. MCR did not change 36 to 72 hr after transplantation but reached normal values 7 to 15 days after transplantation. UCR of 125I-insulin is sometimes increased in some patients with a renal graft; even in those circumstances, the UCR remains negligible and the MCR almost entirely accounts for the TCR.
- Subjects
INSULIN; CHRONIC kidney failure; KIDNEY transplantation; TRANSPLANTATION of organs, tissues, etc.; KIDNEYS; URINARY organs; GENITOURINARY organs
- Publication
Kidney International, 1974, Vol 5, Issue 5, p372
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1974.53