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- Title
T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure.
- Authors
Iwase, Saori C; Edlefsen, Paul T; Bhebhe, Lynnette; Motsumi, Kesego; Moyo, Sikhulile; Happel, Anna-Ursula; Shao, Danica; Mmasa, Nicholas; Schenkel, Sara; Gasper, Melanie A; Dubois, Melanie; Files, Megan A; Seshadri, Chetan; Duffy, Fergal; Aitchison, John; Netea, Mihai G; Jao, Jennifer; Cameron, Donald W; Gray, Clive M; Jaspan, Heather B
- Abstract
Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9–18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.
- Subjects
SOUTH Africa; TUBERCULOSIS epidemiology; TUBERCULOSIS diagnosis; HIV infections; PRENATAL exposure delayed effects; COMPARATIVE studies; RESEARCH funding; BLOOD testing; ENVIRONMENTAL exposure; FETUS
- Publication
Clinical Infectious Diseases, 2023, Vol 77, Issue 8, p1133
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciad356