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- Title
Comparative analysis of antioxidant, antidiabetic and analgesic activity of Callestemon viminalis L. and Alcea rosea L. leaves extracts.
- Authors
Ahmed, Khwaja Zafar; Naeem, Sadaf; Shafique, Yousra; Khan, Saira Saeed; Alam, Nausheen; Shahnaz, Saira; Tahir, Anosh
- Abstract
High levels of reactive oxygen species (ROS) in the body and diabetes are key factors for the development of hypercholesteremia and related neuropathic pains. Current study aimed to compare the antioxidant, antidiabetic and analgesic activities of aqueous methanolic extracts of C. viminalis L. and A. rosea L. leaves. HPLC method was used for phenolic content evaluation. Antioxidant capacity was determined by DPPH and analgesic activity was performed via acetic acid induced writhing reflex test. Whereas the antidiabetic activity was performed on Alloxan induced diabetes model. HPLC analysis indicated the presence of phenols in both extracts. Based on DPPH radical scavenging activity, C. viminalis and A.rosea L. both leaves extracts showed strong scavenging activity (IC50, 11.96±0.64lg/mL) and (IC50, 10.11±0.74lg/mL) respectively. Antidiabetic effect of C. viminalis L and A. rosea L. were also significant (p<0.05). Further biochemical analysis showed both leaves extracts significantly (P<0.05) reduces glucose, Low density lipid (LDL), triglycerides (TG), total cholesterol (TC) and urea while high density lipid (HDL) were improved. In writhing reflex test both extracts exhibited significant (P<0.01) analgesic activity which was comparable to Aspirin. In conclusion both C. viminalis L. and A. rosea L. leaves extracts displayed significant antioxidant, analgesic and antidiabetic activity.
- Subjects
ANTIOXIDANT analysis; HYPOGLYCEMIC agents; ALLOXAN diabetes; REACTIVE oxygen species; COMPARATIVE studies; CHOLESTEROL content of food
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2023, Vol 36, Issue 2, p467
- ISSN
1011-601X
- Publication type
Article
- DOI
10.36721/PJPS.2023.36.2.REG.467-476.1