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- Title
Antiviral activity of Salidroside from the leaves of Nigerian mistletoe (Loranthus micranthus Linn) parasitic on Hevea brasiliensis against respiratory syncytial virus.
- Authors
Agbo, Matthias Onyebuchi; Odimegwu, Damian Chukwu; Chiedu Okoye, Festus Basden; Osadebe, Patience Ogoamaka
- Abstract
Isolated Salidroside from the leaves of Nigerian mistletoe (Loranthus micranthus Linn) parasitic on Hevea brasiliensis was evaluated for its antiviral activity against respiratory syncytial virus. Semi- preparative HPLC separation of the ethyl acetate fraction of the leave extract of Loranthus micranthus Linn parasitic on Hevea brasiliensis led to the isolation of a polyphenol. Using spectroscopic methods (1D and 2D NMR and mass spectroscopic data) as well as by comparison with literature data the structure of the compound was determined as 6-O-galloyl salidroside. The antiviral activity of the isolated compound was evaluated against the respiratory syncytial virus. The isolated Salidroside showed potent inhibition towards a recombinant straining respiratory syncytial virus with Inhibitory Concentration (IC50) value of 10.3±1.50 μg/mL. The result indicates that Salidroside is an efficient antiviral agent against RSV infection and might be useful for the management of RSV pathogenesis.
- Subjects
ANTIVIRAL agents; HEVEA; MISTLETOES; RNA virus infections; RUBBER plants; REPRODUCTION
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2017, Vol 30, Issue 4, p1251
- ISSN
1011-601X
- Publication type
Article